Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1)

Purpose

The trial will evaluate efficacy, safety and tolerability of two regimens of ianalumab compared to placebo, given as monthly or quarterly subcutaneous (s.c.) injection on top of standard-of-care (SoC) treatment in participants with active systemic lupus erythematosus (SLE).

Condition

  • Systemic Lupus Erythematosus

Eligibility

Eligible Ages
Over 12 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Male and female participants aged 12 years or older at the time of screening, or limited to 18 years or older in European Economic Area countries and other countries where inclusion of participants below 18 years is not allowed. - Diagnosis of systemic lupus erythematosus meeting the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) SLE classification criteria at least 6 months prior to screening. - Elevated serum titers at screening of anti-nuclear antibodies ≥ 1:80 as determined by a central laboratory with a SLE-typical fluorescence pattern. - Currently receiving CS and/or anti-malarial treatment and/or another disease-modifying antirheumatic drug (DMARD) as specified in the protocol. - SLEDAI-2K criteria at screening: SLEDAI-2K score ≥ 6 points, excluding points attributed to "fever", "lupus headache", "alopecia", and "organic brain syndrome" - BILAG-2004 disease activity level at screening of at least 1 of the following: - BILAG-2004 level 'A' disease in ≥ 1 organ system, Or - BILAG-2004 level 'B' disease in ≥ 2 organ systems - Weigh at least 35 kg at screening

Exclusion Criteria

  • Prior treatment with ianalumab - History of receiving following treatment: I) high dose CS, calcineurin inhibitors, JAK or other kinase inhibitors or other DMARD (except as listed in inclusion criteria) administered within 12 weeks prior to screening. II) cyclophosphamide or biologics such as immunoglobulins (intravenous or s.c.), plasmapheresis, anti-type I interferon receptor biologic agents, anti-CD40 agents, CTLA4-Fc Ig or B-cell activating factor (BAFF)-targeting agents administered within 24 weeks prior to screening; belimumab administered within 12 weeks prior to screening. III) any B cell-depleting therapies, other than ianalumab administered within 36 weeks prior to randomization or as long as B cell count is less than the lower limit of normal or baseline value prior to receipt of B cell-depleting therapy (whichever is lower). IV) Traditional Chinese medicines administered within 30 days prior to randomization. - Active viral, bacterial or other infections requiring intravenous or intramuscular treatment for clinically significant infection - Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) - Evidence of active tuberculosis infection - History of primary or secondary immunodeficiency, including a positive human immunodeficiency virus (HIV) test result at screening - Any one of the following abnormal laboratory values prior to randomization - Platelets < 25000/mm^3 (< 25 x 10^3/μL) - Hemoglobin (Hgb) < 8.0 g/dL (< 5 mmol/L), or < 7.0 g/dL (< 4.3 mmol/L) if related to participant's SLE such as in active hemolytic anaemia - Absolute neutrophil count (ANC) (< 0.8 x 10^3/ μL) - Severe organ dysfunction or life-threatening disease at screening - Presence of severe lupus kidney disease as defined by proteinuria above 2 g/day or equivalent using spot urine protein creatinine ratio, or serum creatinine greater than 2.0 mg/dL (176.84 µmol/L), or requiring immune-suppressive induction or maintenance treatment at screening - Receipt of live/attenuated vaccine within a 4-week period before first dosing - Any uncontrolled, co-existing serious disease, which in the opinion of the investigator will place the participant at risk for participation or interfere with evaluation for SLE-related symptoms - Non-lupus conditions such as asthma, gout or urticaria, requiring intermittent or chronic treatment with systemic CS - History of malignancy of any organ system other than localized basal cell carcinoma of the skin or in situ cervical cancer - Pregnant or nursing (lactating) women. - Women of child-bearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception while on study treatment and for 6 months after stopping of investigational drug. - Any surgical, medical, psychiatric or additional physical condition that may jeopardize participation in this study

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Intervention Model Description
The trial is designed to evaluate efficacy, safety and tolerability of two regimens of ianalumab compared to placebo, given as monthly or quarterly subcutaneous (s.c.) injection on top of standard-of-care (SoC) treatment in participants with active systemic lupus erythematosus (SLE).
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Ianalumab s.c. monthly
Ianalumab s.c. monthly
  • Drug: Ianalumab
    ianalumab s.c. monthly or quarterly
    Other names:
    • VAY736
Experimental
Ianalumab s.c. quarterly
Ianalumab s.c. quarterly
  • Drug: Ianalumab
    ianalumab s.c. monthly or quarterly
    Other names:
    • VAY736
Placebo Comparator
Placebo s.c. monthly
placebo s.c. monthly
  • Drug: Placebo
    placebo s.c. monthly

Recruiting Locations

Medical Center Main Campus
Cleveland, Ohio 44109
Contact:
Maggie Washington
216-778-7800
mwashington3@metrohealth.org

More Details

Status
Recruiting
Sponsor
Novartis Pharmaceuticals

Study Contact

Novartis Pharmaceuticals
1-888-669-6682
novartis.email@novartis.com

Detailed Description

A randomized, double-blind, parallel group, placebo-controlled multicenter phase 3 study to evaluate efficacy, safety and tolerability of two regimens of ianalumab on top of standard-of-care therapy in patients with systemic lupus erythematosus (SIRIUS-SLE 1)